PET/CT-perfusion may predict radio-chemo failure in head and neck cancer patients

January 21, 2016 - Combined PET/CT with integrated CTP might show complementary prognostic data pre- and post chemo-radiotherapy, according to the findings in a recent study.1

While 18F]FDG-PET/CT imaging is broadly used in head and neck cancer (HNSCC) patients, CT perfusion (CTP) is known to provide information about angiogenesis and blood-flow characteristics in tumors. The authors designed a study to evaluate the potential relationship of FDG-parameters and CTP-parameters in HNSCC preand post-therapy and the potential prognostic value of a combined PET/CT with CTP.

Thirteen patients with histologic proven HNSCC were prospectively included. All patients underwent a combined PET/CT with integrated CTP before and after therapy. Pre- and post-therapeutic data of CTP and PET of the tumors were compared. Differences were tested using Spearman’s rho test and Pearson’s correlation. A p-value of p <0.05 was considered statistically significant. Correlations were calculated using Pearson’s correlation. Bootstrap confidence intervals were calculated to test for additive confidence intervals.

Three patients died due to malignancy recurrence, ten patients were free of recurrence until the end of the follow-up period. Patients with recurrent disease had significantly higher initial CTP-values compared to the recurrence-free patients: BFpre 267.4 (171.2)ml/100 mg/min, BVpre 40.9 (8.4)ml/100 mg and MTTpre 8.2 (6.1)sec. No higher SUVs initially but significantly higher TLG compared to patients without recurrence were found. Post-therapeutic PET-values differed significantly between the two groups: SUVmaxpost 6.0 (3.2), SUVmeanpost 3.6 (2.0) and TLG 21751.7 (29794.0).

The authors concluded that combined PET/CT with integrated CTP might show complementary prognostic data pre- and post chemo-radiotherapy, and that CTP may be used to predict local tumor recurrence, while FDGPET/CT is still needed for whole-body staging.


1. Pietsch C, de Galiza Barbosa F, Hüllner MW, et al. Combined PET/CT-perfusion in patients with head and neck cancers might predict failure after radio-chemotherapy: a proof of concept study. BMC Medical Imaging201515:60.DOI: 10.1186/s12880-015-0102-z